Abstract
We report on the development of substituted valero enol lactones as powerful inhibitors of human neutrophil elastase (HNE) by valine mimic enol lactones and trypsin-like enzymes (trypsin, plasmin, urokinase, t-PA, and thrombin) by guanidino-aryl substituted enol lactones.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1399-1404 |
| Number of pages | 6 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 2 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1992 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
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