Enol lactone derivatives as inhibitors of human neutrophil elastase and trypsin-like proteases

John A. Katzenellenbogen; Roopa Rai; Wei Dai

doi:10.1016/S0960-894X(00)80521-1

Enol lactone derivatives as inhibitors of human neutrophil elastase and trypsin-like proteases

John A. Katzenellenbogen, Roopa Rai, Wei Dai

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

We report on the development of substituted valero enol lactones as powerful inhibitors of human neutrophil elastase (HNE) by valine mimic enol lactones and trypsin-like enzymes (trypsin, plasmin, urokinase, t-PA, and thrombin) by guanidino-aryl substituted enol lactones.

Original language	English (US)
Pages (from-to)	1399-1404
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	2
Issue number	11
DOIs	https://doi.org/10.1016/S0960-894X(00)80521-1
State	Published - Nov 1992

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(00)80521-1

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title = "Enol lactone derivatives as inhibitors of human neutrophil elastase and trypsin-like proteases",

abstract = "We report on the development of substituted valero enol lactones as powerful inhibitors of human neutrophil elastase (HNE) by valine mimic enol lactones and trypsin-like enzymes (trypsin, plasmin, urokinase, t-PA, and thrombin) by guanidino-aryl substituted enol lactones.",

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AB - We report on the development of substituted valero enol lactones as powerful inhibitors of human neutrophil elastase (HNE) by valine mimic enol lactones and trypsin-like enzymes (trypsin, plasmin, urokinase, t-PA, and thrombin) by guanidino-aryl substituted enol lactones.

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Enol lactone derivatives as inhibitors of human neutrophil elastase and trypsin-like proteases

Abstract

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