Engineering unnatural variants of plantazolicin through codon reprogramming

Biochemistry, Genetics and Molecular Biology

• Precursor 100%
• Enzyme 100%
• Codon 100%
• Reprogramming 100%
• Structure Activity Relation 66%
• Anabolism 66%
• Escherichia coli 66%
• Bacillus Anthracis 66%
• Site-Directed Mutagenesis 33%
• Posttranslational Modification 33%
• Mass Spectrometry 33%
• Alpha Oxidation 33%
• Peptide Sequence 33%
• Copurification 33%
• Maturation 33%
• Antibacterial Activity 33%
• Microcin 33%
• Thiazole 33%

Keyphrases

• Codon 100%
• Unnatural 100%
• Plantazolicin 100%
• Heterocycles 36%
• Biosynthetic Pathway 18%
• Precursor Peptide 18%
• Structure-activity Relationship 18%
• Post-translational Modification 9%
• Mass Spectrometry 9%
• Oxidation State 9%
• Site-directed mutagenesis 9%
• Escherichia Coli 9%
• Peptide Sequencing 9%
• Causative Agents 9%
• Natural Products 9%
• Antibiotics 9%
• Bacillus Anthracis 9%
• Biosynthetic Cluster 9%
• Post-translational 9%
• Substrate Tolerance 9%
• Escherichia Coli Expression 9%
• Antibacterial Activity 9%
• Oxazole 9%
• Expression Strain 9%
• Thiazole 9%
• Microcin 9%
• Ribosomal Peptide 9%
• Polyheterocyclic 9%
• Anthrax 9%
• Neighboring Residues 9%

Chemistry

• Heterocyclic Compound 100%
• Primary Structure 50%
• Structure-Activity Relationship 50%
• Mass Spectrometry 25%
• Site-Directed Mutagenesis 25%
• Occurrence in Nature 25%
• Antibacterial 25%
• Microcin 25%
• Thiazole 25%
• Oxazole 25%