Engineering robust microorganisms for organic acid production

Vinh G. Tran, Huimin Zhao

Research output: Contribution to journalReview articlepeer-review


Organic acids are an important class of compounds that can be produced by microbial conversion of renewable feedstocks and have huge demands and broad applications in food, chemical, and pharmaceutical industries. An economically viable fermentation process for production of organic acids requires robust microbial cell factories with excellent tolerance to low pH conditions, high concentrations of organic acids, and lignocellulosic inhibitors. In this review, we summarize various strategies to engineer robust microorganisms for organic acid production and highlight their applications in a few recent examples.

Original languageEnglish (US)
Article numberkuab067
JournalJournal of Industrial Microbiology and Biotechnology
Issue number2
StatePublished - Mar 1 2022


  • Acid stress
  • Lignocellulosic inhibitors
  • Low pH
  • Organic acids
  • Robustness

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Bioengineering
  • Biotechnology


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