Engineering of Saccharomyces cerevisiae for efficient fermentation of cellulose

Eun Joong Oh, Yong Su Jin

Research output: Contribution to journalReview articlepeer-review


Conversion of lignocellulosic biomass to biofuels using microbial fermentation is an attractive option to substitute petroleum-based production economically and sustainably. The substantial efforts to design yeast strains for biomass hydrolysis have led to industrially applicable biological routes. Saccharomyces cerevisiae is a robust microbial platform widely used in biofuel production, based on its amenability to systems and synthetic biology tools. The critical challenges for the efficient microbial conversion of lignocellulosic biomass by engineered S. cerevisiae include heterologous expression of cellulolytic enzymes, co-fermentation of hexose and pentose sugars, and robustness against various stresses. Scientists developed many engineering strategies for cellulolytic S. cerevisiae strains, bringing the application of consolidated bioprocess at an industrial scale. Recent advances in the development and implementation of engineered yeast strains capable of assimilating lignocellulose will be reviewed.

Original languageEnglish (US)
Article numberfoz089
JournalFEMS yeast research
Issue number1
StatePublished - Feb 1 2020


  • Biofuel
  • Lignocellulosic biomass
  • Saccharomyces cerevisiae

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology


Dive into the research topics of 'Engineering of Saccharomyces cerevisiae for efficient fermentation of cellulose'. Together they form a unique fingerprint.

Cite this