Engineering of enzymes for selective catalysis

Nikhil U. Nair, Carl A. Denard, Huimin Zhao

Research output: Contribution to journalArticlepeer-review


Naturally occurring enzymes are truly remarkable catalysts. However, many are not suitable for practical synthetic chemistry because of poor substrate or product selectivity. This review highlights recent advances in engineering enzymes for selective catalysis. Selected topics include altering substrate specificity, altering substrate and product selectivity, engineering enzymes that catalyze carbon-carbon bond formation or carbon-oxygen bond cleavage and formation, and engineering multi-function enzymes such as polyketide synthases.

Original languageEnglish (US)
Pages (from-to)1870-1882
Number of pages13
JournalCurrent Organic Chemistry
Issue number17
StatePublished - 2010


  • Biocatalysis
  • Directed evolution
  • Enzyme engineering
  • Selectivity

ASJC Scopus subject areas

  • Organic Chemistry


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