TY - JOUR
T1 - Engineering of biomaterials for tumor modeling
AU - Choi, S. R.
AU - Yang, Y.
AU - Huang, K. Y.
AU - Kong, H. J.
AU - Flick, M. J.
AU - Han, B.
N1 - Funding Information:
This work is partially supported by grants from National Institutes of Health ( U01 HL143403 , UL1 TR002529 to BH, and R01 CA211098 , U01 HL143403 , R01 DK112778 to MJF), National Science Foundation ( STC-EBICS , CBET-0939511 , and CBET-1932192 to HJK), a Challenge Award from the Purdue Center for Cancer Research (P30 CA023168), and the Walther Embedding Program in Physical Sciences in Oncology. SC is supported by Laura Winkelman Davidson Fellowship.
Publisher Copyright:
© 2020 The Author(s)
PY - 2020/12
Y1 - 2020/12
N2 - Development of biomaterials mimicking tumor and its microenvironment has recently emerged for the use of drug discovery, precision medicine, and cancer biology. These biomimetic models have developed by reconstituting tumor and stroma cells within the 3D extracellular matrix. The models are recently extended to recapitulate the in vivo tumor microenvironment, including biological, chemical, and mechanical conditions tailored for specific cancer type and its microenvironment. In spite of the recent emergence of various innovative engineered tumor models, many of these models are still early stage to be adapted for cancer research. In this article, we review the current status of biomaterials engineering for tumor models considering three main aspects—cellular engineering, matrix engineering, and engineering for microenvironmental conditions. Considering cancer-specific variability in these aspects, our discussion is focused on pancreatic cancer, specifically pancreatic ductal adenocarcinoma. In addition, we further discussed the current challenges and future opportunities to create reliable and relevant tumor models.
AB - Development of biomaterials mimicking tumor and its microenvironment has recently emerged for the use of drug discovery, precision medicine, and cancer biology. These biomimetic models have developed by reconstituting tumor and stroma cells within the 3D extracellular matrix. The models are recently extended to recapitulate the in vivo tumor microenvironment, including biological, chemical, and mechanical conditions tailored for specific cancer type and its microenvironment. In spite of the recent emergence of various innovative engineered tumor models, many of these models are still early stage to be adapted for cancer research. In this article, we review the current status of biomaterials engineering for tumor models considering three main aspects—cellular engineering, matrix engineering, and engineering for microenvironmental conditions. Considering cancer-specific variability in these aspects, our discussion is focused on pancreatic cancer, specifically pancreatic ductal adenocarcinoma. In addition, we further discussed the current challenges and future opportunities to create reliable and relevant tumor models.
KW - Biomaterials
KW - Cancer cells
KW - Extracellular matrix
KW - Tumor microenvironment
KW - Tumor model
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U2 - 10.1016/j.mtadv.2020.100117
DO - 10.1016/j.mtadv.2020.100117
M3 - Review article
C2 - 34541484
AN - SCOPUS:85096189980
VL - 8
JO - Materials Today Advances
JF - Materials Today Advances
SN - 2590-0498
M1 - 100117
ER -