Engineering novel metalloproteins: Design of metal-binding sites into native protein scaffolds

Yi Lu, Steven M. Berry, Thomas D. Pfister

Research output: Contribution to journalReview article

Abstract

The design of metal binding sites into native protein scaffolds was discussed. Most native scaffolds have high thermodynamic stability and extraordinary tolerance for residue substitution, deletion and insertion. The resulting protein can more often assume globular rather than molten globular forms and is more amenable to spectroscopic and x ray crystallographic characterization.

Original languageEnglish (US)
Pages (from-to)3047-3080
Number of pages34
JournalChemical reviews
Volume101
Issue number10
DOIs
StatePublished - Oct 1 2001

ASJC Scopus subject areas

  • Chemistry(all)

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