Engineering neural networks in vitro: microstamping biomolecules to control cell position

Bruce C. Wheeler; Darren W. Branch; Joseph M. Corey; James A. Weyhenmeyer; Gregory J. Brewer

Engineering neural networks in vitro: microstamping biomolecules to control cell position

Bruce C. Wheeler, Darren W. Branch, Joseph M. Corey, James A. Weyhenmeyer, Gregory J. Brewer

Research output: Contribution to journal › Conference article › peer-review

Abstract

We have developed a technique in which biomolecules may be stamped on glassy substrates in arbitrary patterns, with micrometer resolution, and in multiple layers. The silicone rubber microstamps are formed from micromachined (by reactive ion-etch) polyimide molds. Fluorescene patterns demonstrate efficacy in biomolecule transfer. Patterns of stamped and photoresist patterned polylysine are equally effective in controlling growth of neuroblastoma cells. The technique is promising for the creation of biological neural networks in culture.

Original language	English (US)
Pages (from-to)	2582-2585
Number of pages	4
Journal	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	6
State	Published - 1997
Event	Proceedings of the 1997 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Chicago, IL, USA Duration: Oct 30 1997 → Nov 2 1997

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

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title = "Engineering neural networks in vitro: microstamping biomolecules to control cell position",

abstract = "We have developed a technique in which biomolecules may be stamped on glassy substrates in arbitrary patterns, with micrometer resolution, and in multiple layers. The silicone rubber microstamps are formed from micromachined (by reactive ion-etch) polyimide molds. Fluorescene patterns demonstrate efficacy in biomolecule transfer. Patterns of stamped and photoresist patterned polylysine are equally effective in controlling growth of neuroblastoma cells. The technique is promising for the creation of biological neural networks in culture.",

author = "Wheeler, {Bruce C.} and Branch, {Darren W.} and Corey, {Joseph M.} and Weyhenmeyer, {James A.} and Brewer, {Gregory J.}",

year = "1997",

language = "English (US)",

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publisher = "Institute of Electrical and Electronics Engineers Inc.",

note = "Proceedings of the 1997 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society ; Conference date: 30-10-1997 Through 02-11-1997",

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T2 - Proceedings of the 1997 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society

AU - Wheeler, Bruce C.

AU - Branch, Darren W.

AU - Corey, Joseph M.

AU - Weyhenmeyer, James A.

AU - Brewer, Gregory J.

PY - 1997

Y1 - 1997

N2 - We have developed a technique in which biomolecules may be stamped on glassy substrates in arbitrary patterns, with micrometer resolution, and in multiple layers. The silicone rubber microstamps are formed from micromachined (by reactive ion-etch) polyimide molds. Fluorescene patterns demonstrate efficacy in biomolecule transfer. Patterns of stamped and photoresist patterned polylysine are equally effective in controlling growth of neuroblastoma cells. The technique is promising for the creation of biological neural networks in culture.

AB - We have developed a technique in which biomolecules may be stamped on glassy substrates in arbitrary patterns, with micrometer resolution, and in multiple layers. The silicone rubber microstamps are formed from micromachined (by reactive ion-etch) polyimide molds. Fluorescene patterns demonstrate efficacy in biomolecule transfer. Patterns of stamped and photoresist patterned polylysine are equally effective in controlling growth of neuroblastoma cells. The technique is promising for the creation of biological neural networks in culture.

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SN - 1557-170X

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JF - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference

Y2 - 30 October 1997 through 2 November 1997

ER -

Engineering neural networks in vitro: microstamping biomolecules to control cell position

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