Engineering neural networks in vitro: microstamping biomolecules to control cell position

Bruce C. Wheeler, Darren W. Branch, Joseph M. Corey, James A. Weyhenmeyer, Gregory J. Brewer

Research output: Contribution to journalConference articlepeer-review

Abstract

We have developed a technique in which biomolecules may be stamped on glassy substrates in arbitrary patterns, with micrometer resolution, and in multiple layers. The silicone rubber microstamps are formed from micromachined (by reactive ion-etch) polyimide molds. Fluorescene patterns demonstrate efficacy in biomolecule transfer. Patterns of stamped and photoresist patterned polylysine are equally effective in controlling growth of neuroblastoma cells. The technique is promising for the creation of biological neural networks in culture.

Original languageEnglish (US)
Pages (from-to)2582-2585
Number of pages4
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume6
StatePublished - 1997
EventProceedings of the 1997 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Chicago, IL, USA
Duration: Oct 30 1997Nov 2 1997

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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