TY - JOUR
T1 - Engineering microbial factories for synthesis of value-added products
AU - Du, Jing
AU - Shao, Zengyi
AU - Zhao, Huimin
N1 - Funding Information:
We thank the National Institutes of Health (GM077596), the National Academies Keck Futures Initiative on Synthetic Biology, the Biotechnology Research and Development Consortium (BRDC) (Project 2-4-121), the British Petroleum Energy Biosciences Institute, and the National Science Foundation as part of the Center for Enabling New Technologies through Catalysis (CENTC), CHE-0650456, and the National Research Foundation of Korea (NRF) (220-2009-1-D00033) for financial support. J. Du also acknowledges both the Chia-chen Chu graduate fellowship from the School of Chemical Sciences and the Henry Drickamer Fellowship support from the Department of Chemical and Biomolecular Engineering at the University of Illinois.
PY - 2011/8
Y1 - 2011/8
N2 - Microorganisms have become an increasingly important platform for the production of drugs, chemicals, and biofuels from renewable resources. Advances in protein engineering, metabolic engineering, and synthetic biology enable redesigning microbial cellular networks and fine-tuning physiological capabilities, thus generating industrially viable strains for the production of natural and unnatural value-added compounds. In this review, we describe the recent progress on engineering microbial factories for synthesis of valued-added products including alkaloids, terpenoids, flavonoids, polyketides, non-ribosomal peptides, biofuels, and chemicals. Related topics on lignocellulose degradation, sugar utilization, and microbial tolerance improvement will also be discussed.
AB - Microorganisms have become an increasingly important platform for the production of drugs, chemicals, and biofuels from renewable resources. Advances in protein engineering, metabolic engineering, and synthetic biology enable redesigning microbial cellular networks and fine-tuning physiological capabilities, thus generating industrially viable strains for the production of natural and unnatural value-added compounds. In this review, we describe the recent progress on engineering microbial factories for synthesis of valued-added products including alkaloids, terpenoids, flavonoids, polyketides, non-ribosomal peptides, biofuels, and chemicals. Related topics on lignocellulose degradation, sugar utilization, and microbial tolerance improvement will also be discussed.
KW - Fuels and chemicals
KW - Metabolic engineering
KW - Microbial synthesis
KW - Natural products
KW - Synthetic biology
KW - Value-added products
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U2 - 10.1007/s10295-011-0970-3
DO - 10.1007/s10295-011-0970-3
M3 - Review article
C2 - 21526386
AN - SCOPUS:80051704380
SN - 1367-5435
VL - 38
SP - 873
EP - 890
JO - Journal of Industrial Microbiology and Biotechnology
JF - Journal of Industrial Microbiology and Biotechnology
IS - 8
ER -