Engineering microbial factories for synthesis of value-added products

Jing Du, Zengyi Shao, Huimin Zhao

Research output: Contribution to journalReview articlepeer-review


Microorganisms have become an increasingly important platform for the production of drugs, chemicals, and biofuels from renewable resources. Advances in protein engineering, metabolic engineering, and synthetic biology enable redesigning microbial cellular networks and fine-tuning physiological capabilities, thus generating industrially viable strains for the production of natural and unnatural value-added compounds. In this review, we describe the recent progress on engineering microbial factories for synthesis of valued-added products including alkaloids, terpenoids, flavonoids, polyketides, non-ribosomal peptides, biofuels, and chemicals. Related topics on lignocellulose degradation, sugar utilization, and microbial tolerance improvement will also be discussed.

Original languageEnglish (US)
Pages (from-to)873-890
Number of pages18
JournalJournal of Industrial Microbiology and Biotechnology
Issue number8
StatePublished - Aug 2011


  • Fuels and chemicals
  • Metabolic engineering
  • Microbial synthesis
  • Natural products
  • Synthetic biology
  • Value-added products

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology


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