Engineering microbial factories for synthesis of value-added products

Jing Du, Zengyi Shao, Huimin Zhao

Research output: Contribution to journalReview article

Abstract

Microorganisms have become an increasingly important platform for the production of drugs, chemicals, and biofuels from renewable resources. Advances in protein engineering, metabolic engineering, and synthetic biology enable redesigning microbial cellular networks and fine-tuning physiological capabilities, thus generating industrially viable strains for the production of natural and unnatural value-added compounds. In this review, we describe the recent progress on engineering microbial factories for synthesis of valued-added products including alkaloids, terpenoids, flavonoids, polyketides, non-ribosomal peptides, biofuels, and chemicals. Related topics on lignocellulose degradation, sugar utilization, and microbial tolerance improvement will also be discussed.

Original languageEnglish (US)
Pages (from-to)873-890
Number of pages18
JournalJournal of Industrial Microbiology and Biotechnology
Volume38
Issue number8
DOIs
StatePublished - Aug 1 2011

Fingerprint

Biofuels
Industrial plants
Synthetic Biology
Metabolic engineering
Metabolic Engineering
Polyketides
Protein Engineering
Flavonoids
Alkaloids
Terpenes
Sugars
Microorganisms
Peptides
Tuning
Proteins
Degradation
Pharmaceutical Preparations
lignocellulose

Keywords

  • Fuels and chemicals
  • Metabolic engineering
  • Microbial synthesis
  • Natural products
  • Synthetic biology
  • Value-added products

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Engineering microbial factories for synthesis of value-added products. / Du, Jing; Shao, Zengyi; Zhao, Huimin.

In: Journal of Industrial Microbiology and Biotechnology, Vol. 38, No. 8, 01.08.2011, p. 873-890.

Research output: Contribution to journalReview article

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