Engineering metal-binding sites in proteins

Yi Lu, Joan S. Valentine

Research output: Contribution to journalArticlepeer-review


Metal-binding sites have been engineered into both de novo designed and naturally occurring proteins. Although the redesign of existing metal-binding sites in naturally occurring proteins still offers the most promise for a successful design, the more challenging goal of engineering metal-binding sites in de novo designed proteins and peptides is being achieved with increasing frequency. Creating new metal-binding sites in naturally occurring proteins combines the strength of both approaches. Currently, all three approaches are being used effectively in elucidating the structure and function of naturally occurring metalloproteins.

Original languageEnglish (US)
Pages (from-to)495-500
Number of pages6
JournalCurrent Opinion in Structural Biology
Issue number4
StatePublished - Aug 1997

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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