Engineering Dehydro Amino Acids and Thioethers into Peptides Using Lacticin 481 Synthetase

Keyphrases

• Amino Acids 100%
• Thioether 100%
• Synthetase 100%
• Lacticin 100%
• Homocysteine 66%
• Cyclization 33%
• Antimicrobial 33%
• Non-proteinogenic 33%
• Proteinogenic Amino Acids 33%
• Cysteine Analog 33%
• Peptidic 33%
• Semi-synthetic 33%
• Thioether Linkage 33%
• Substrate Tolerance 33%
• Lanthionine 33%
• Lantibiotics 33%
• Dehydroalanine 33%
• Dehydrobutyrine 33%
• Conformationally Constrained Peptides 33%
• In Vitro Processing 33%
• Peptide Drugs 33%
• Chemoenzymatic Strategy 33%

Biochemistry, Genetics and Molecular Biology

• Amino Acids 100%
• Thioether 100%
• Homocysteine 50%
• Gene Linkage 25%
• Antimicrobial Peptides 25%
• Lantibiotic 25%
• Cysteine 25%
• Lanthionine 25%

Chemistry

• Amino Acid 100%
• Homocysteine 66%
• Polypeptide Antibiotic Agent 33%
• Lantibiotic 33%
• Dehydroalanine Residue 33%
• Proteinogenic Amino Acid 33%
• Lanthionine 33%
• Cysteine 33%