Keyphrases
Cleavage Activity
100%
Cytochrome P450 Monooxygenase
100%
C-C Bond Cleavage
100%
Lyase
100%
α-Hydroxy Ketones
100%
P450
60%
CYP17A1
60%
Cleavage Reactions
40%
Catalytic Cycle
20%
Molecular Dynamics Simulation
20%
Active Sites
20%
Structural Characterization
20%
Transition State
20%
Biophysical Characterization
20%
Heteroatom
20%
Low Activity
20%
Benzoic Acid
20%
Epoxidation
20%
Compound I
20%
Oxygen Binding
20%
Sulfoxidation
20%
Cytochrome P450 (CYP450)
20%
Hydroxylation
20%
Carbon-carbon Bond Cleavage
20%
Probe-based
20%
Physiological Substrates
20%
Carbon-carbon Bond Formation
20%
Mechanistic Details
20%
Co-crystallization
20%
Solvent Isotope Effect
20%
Kinetic Solvent Isotope Effect
20%
Catalytic Intermediates
20%
Desaturation
20%
C-C Cleavage
20%
S-enantiomer
20%
Cytochrome P450 Superfamily
20%
Heme Monooxygenases
20%
Microbial Systems
20%
Dealkylation
20%
Inverse Kinetics
20%
Carbon-carbon Cleavage
20%
Immunology and Microbiology
Monooxygenase
100%
Cytochrome P450
100%
Wild Type
50%
Fatty Acid Desaturation
50%
Enantiomer
50%
Hydroxylation
50%
Sulfoxidation
50%
Epoxidation
50%
Dealkylation
50%
Heme
50%
Chemistry
Monooxygenase
100%
Cytochrome P450
100%
Ketone
50%
Ketones
33%
Lyase Reaction
33%
formation
33%
Isotope Effect
33%
Molecular Dynamics
16%
Transition State
16%
Heteroatom
16%
Benzoic Acid
16%
Metabolic
16%
Dealkylation
16%
Co Crystallization
16%
hydroxylation
16%
Heme
16%
epoxidation
16%
catalytic cycle
16%
Enantiomer
16%
Biochemistry, Genetics and Molecular Biology
Enzyme
100%
Unspecific Monooxygenase
100%
Cytochrome P450
100%
Lyase
83%
CYP17A1
50%
Active Site
16%
Wild Type
16%
Enantiomer
16%
Sulfoxidation
16%
Hydroxylation
16%
Fatty Acid Desaturation
16%
Epoxidation
16%
Dealkylation
16%
Pharmacology, Toxicology and Pharmaceutical Science
Cytochrome P450
100%
Bond Cleavage
100%
Unspecific Monooxygenase
100%
Lyase
83%
CYP17A1
50%
Crystallization
16%
Heme
16%
Benzoic Acid
16%
Carbon-Carbon Bond
16%
Medicine and Dentistry
Cytochrome P450
100%
Unspecific Monooxygenase
100%
Lyase
83%
CYP17A1
50%
Hydroxylation
16%
Heme
16%
Fatty Acid Desaturation
16%
Benzoic Acid
16%