Keyphrases
Cleavage Activity
100%
Cytochrome P450 Monooxygenase
100%
C-C Bond Cleavage
100%
Lyase
100%
α-Hydroxy Ketones
100%
P450
60%
CYP17A1
60%
Cleavage Reactions
40%
Catalytic Cycle
20%
Molecular Dynamics Simulation
20%
Active Sites
20%
Structural Characterization
20%
Transition State
20%
Biophysical Characterization
20%
Heteroatom
20%
Low Activity
20%
Benzoic Acid
20%
Epoxidation
20%
Compound I
20%
Oxygen Binding
20%
Sulfoxidation
20%
Cytochrome P450 (CYP450)
20%
Hydroxylation
20%
Carbon-carbon Bond Cleavage
20%
Probe-based
20%
Physiological Substrates
20%
Carbon-carbon Bond Formation
20%
Mechanistic Details
20%
Co-crystallization
20%
Solvent Isotope Effect
20%
Kinetic Solvent Isotope Effect
20%
Catalytic Intermediates
20%
Desaturation
20%
C-C Cleavage
20%
S-enantiomer
20%
Cytochrome P450 Superfamily
20%
Heme Monooxygenases
20%
Microbial Systems
20%
Dealkylation
20%
Inverse Kinetics
20%
Carbon-carbon Cleavage
20%
Immunology and Microbiology
Dynamics
100%
Heme
100%
Wild Type
100%
Fatty Acid Desaturation
100%
Enantiomer
100%
Hydroxylation
100%
Sulfoxidation
100%
Epoxidation
100%
Dealkylation
100%
Chemistry
Monooxygenase
100%
Ketone
100%
Ketones
66%
Isotope Effect
66%
Cytochrome P450
66%
Lyase Reaction
66%
Structure
33%
Enantiomer
33%
Molecular Dynamics
33%
Heme
33%
Transition State
33%
Hydroxylation
33%
Heteroatom
33%
Benzoic Acid
33%
Metabolic
33%
Epoxidation
33%
Dealkylation
33%
Co Crystallization
33%
Biochemistry, Genetics and Molecular Biology
Enzyme
100%
Lyase
100%
Unspecific Monooxygenase
100%
CYP17A1
60%
Cytochrome P450
40%
Dynamics
20%
Active Site
20%
Wild Type
20%
Enantiomer
20%
Sulfoxidation
20%
Hydroxylation
20%
Fatty Acid Desaturation
20%
Epoxidation
20%
Dealkylation
20%
Pharmacology, Toxicology and Pharmaceutical Science
Cytochrome P450
100%
Bond Cleavage
100%
Unspecific Monooxygenase
100%
Lyase
83%
CYP17A1
50%
Crystallization
16%
Heme
16%
Benzoic Acid
16%
Carbon-Carbon Bond
16%
Medicine and Dentistry
Cytochrome P450
100%
Unspecific Monooxygenase
100%
Lyase
83%
CYP17A1
50%
Hydroxylation
16%
Heme
16%
Fatty Acid Desaturation
16%
Benzoic Acid
16%