Engineering biological systems using automated biofoundries

Ran Chao, Shekhar Mishra, Tong Si, Huimin Zhao

Research output: Contribution to journalReview articlepeer-review


Engineered biological systems such as genetic circuits and microbial cell factories have promised to solve many challenges in the modern society. However, the artisanal processes of research and development are slow, expensive, and inconsistent, representing a major obstacle in biotechnology and bioengineering. In recent years, biological foundries or biofoundries have been developed to automate design-build-test engineering cycles in an effort to accelerate these processes. This review summarizes the enabling technologies for such biofoundries as well as their early successes and remaining challenges.

Original languageEnglish (US)
Pages (from-to)98-108
Number of pages11
JournalMetabolic Engineering
StatePublished - Jul 2017

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


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