Abstract
Engineered biological systems such as genetic circuits and microbial cell factories have promised to solve many challenges in the modern society. However, the artisanal processes of research and development are slow, expensive, and inconsistent, representing a major obstacle in biotechnology and bioengineering. In recent years, biological foundries or biofoundries have been developed to automate design-build-test engineering cycles in an effort to accelerate these processes. This review summarizes the enabling technologies for such biofoundries as well as their early successes and remaining challenges.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 98-108 |
| Number of pages | 11 |
| Journal | Metabolic Engineering |
| Volume | 42 |
| DOIs | |
| State | Published - Jul 2017 |
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ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Applied Microbiology and Biotechnology
Cite this
Engineering biological systems using automated biofoundries. / Chao, Ran; Mishra, Shekhar; Si, Tong; Zhao, Huimin.
In: Metabolic Engineering, Vol. 42, 07.2017, p. 98-108.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Engineering biological systems using automated biofoundries
AU - Chao, Ran
AU - Mishra, Shekhar
AU - Si, Tong
AU - Zhao, Huimin
PY - 2017/7
Y1 - 2017/7
N2 - Engineered biological systems such as genetic circuits and microbial cell factories have promised to solve many challenges in the modern society. However, the artisanal processes of research and development are slow, expensive, and inconsistent, representing a major obstacle in biotechnology and bioengineering. In recent years, biological foundries or biofoundries have been developed to automate design-build-test engineering cycles in an effort to accelerate these processes. This review summarizes the enabling technologies for such biofoundries as well as their early successes and remaining challenges.
AB - Engineered biological systems such as genetic circuits and microbial cell factories have promised to solve many challenges in the modern society. However, the artisanal processes of research and development are slow, expensive, and inconsistent, representing a major obstacle in biotechnology and bioengineering. In recent years, biological foundries or biofoundries have been developed to automate design-build-test engineering cycles in an effort to accelerate these processes. This review summarizes the enabling technologies for such biofoundries as well as their early successes and remaining challenges.
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UR - http://www.scopus.com/inward/citedby.url?scp=85020710659&partnerID=8YFLogxK
U2 - 10.1016/j.ymben.2017.06.003
DO - 10.1016/j.ymben.2017.06.003
M3 - Review article
C2 - 28602523
AN - SCOPUS:85020710659
VL - 42
SP - 98
EP - 108
JO - Metabolic Engineering
JF - Metabolic Engineering
SN - 1096-7176
ER -