TY - JOUR
T1 - Engineering biological systems using automated biofoundries
AU - Chao, Ran
AU - Mishra, Shekhar
AU - Si, Tong
AU - Zhao, Huimin
N1 - Funding Information:
This work was supported by the Roy J. Carver Charitable Trust (13-4257), Carl R. Woese Institute for Genomic Biology at the University of Illinois at Urbana-Champaign (UIUC), Defense Advanced Research Program Agency, and National Institutes of Health (1U54DK107965). R.C. acknowledges fellowship support from 3M Corporation. T.S. acknowledges postdoctoral fellowship support from Carl R. Woese Institute for Genomic Biology (UIUC). We specially thank Dr. Christopher V. Rao and Dr. Weicong Ding for insightful discussions and suggestions.
Publisher Copyright:
© 2017 International Metabolic Engineering Society
PY - 2017/7
Y1 - 2017/7
N2 - Engineered biological systems such as genetic circuits and microbial cell factories have promised to solve many challenges in the modern society. However, the artisanal processes of research and development are slow, expensive, and inconsistent, representing a major obstacle in biotechnology and bioengineering. In recent years, biological foundries or biofoundries have been developed to automate design-build-test engineering cycles in an effort to accelerate these processes. This review summarizes the enabling technologies for such biofoundries as well as their early successes and remaining challenges.
AB - Engineered biological systems such as genetic circuits and microbial cell factories have promised to solve many challenges in the modern society. However, the artisanal processes of research and development are slow, expensive, and inconsistent, representing a major obstacle in biotechnology and bioengineering. In recent years, biological foundries or biofoundries have been developed to automate design-build-test engineering cycles in an effort to accelerate these processes. This review summarizes the enabling technologies for such biofoundries as well as their early successes and remaining challenges.
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U2 - 10.1016/j.ymben.2017.06.003
DO - 10.1016/j.ymben.2017.06.003
M3 - Review article
C2 - 28602523
AN - SCOPUS:85020710659
VL - 42
SP - 98
EP - 108
JO - Metabolic Engineering
JF - Metabolic Engineering
SN - 1096-7176
ER -