Engineering biological systems using automated biofoundries

Ran Chao; Shekhar Mishra; Tong Si; Huimin Zhao

doi:10.1016/j.ymben.2017.06.003

Engineering biological systems using automated biofoundries

Ran Chao, Shekhar Mishra, Tong Si, Huimin Zhao

Research output: Contribution to journal › Review article › peer-review

Abstract

Engineered biological systems such as genetic circuits and microbial cell factories have promised to solve many challenges in the modern society. However, the artisanal processes of research and development are slow, expensive, and inconsistent, representing a major obstacle in biotechnology and bioengineering. In recent years, biological foundries or biofoundries have been developed to automate design-build-test engineering cycles in an effort to accelerate these processes. This review summarizes the enabling technologies for such biofoundries as well as their early successes and remaining challenges.

Original language	English (US)
Pages (from-to)	98-108
Number of pages	11
Journal	Metabolic Engineering
Volume	42
DOIs	https://doi.org/10.1016/j.ymben.2017.06.003
State	Published - Jul 2017

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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title = "Engineering biological systems using automated biofoundries",

abstract = "Engineered biological systems such as genetic circuits and microbial cell factories have promised to solve many challenges in the modern society. However, the artisanal processes of research and development are slow, expensive, and inconsistent, representing a major obstacle in biotechnology and bioengineering. In recent years, biological foundries or biofoundries have been developed to automate design-build-test engineering cycles in an effort to accelerate these processes. This review summarizes the enabling technologies for such biofoundries as well as their early successes and remaining challenges.",

author = "Ran Chao and Shekhar Mishra and Tong Si and Huimin Zhao",

note = "Funding Information: This work was supported by the Roy J. Carver Charitable Trust (13-4257), Carl R. Woese Institute for Genomic Biology at the University of Illinois at Urbana-Champaign (UIUC), Defense Advanced Research Program Agency, and National Institutes of Health (1U54DK107965). R.C. acknowledges fellowship support from 3M Corporation. T.S. acknowledges postdoctoral fellowship support from Carl R. Woese Institute for Genomic Biology (UIUC). We specially thank Dr. Christopher V. Rao and Dr. Weicong Ding for insightful discussions and suggestions.",

year = "2017",

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doi = "10.1016/j.ymben.2017.06.003",

language = "English (US)",

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AU - Mishra, Shekhar

AU - Si, Tong

AU - Zhao, Huimin

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N2 - Engineered biological systems such as genetic circuits and microbial cell factories have promised to solve many challenges in the modern society. However, the artisanal processes of research and development are slow, expensive, and inconsistent, representing a major obstacle in biotechnology and bioengineering. In recent years, biological foundries or biofoundries have been developed to automate design-build-test engineering cycles in an effort to accelerate these processes. This review summarizes the enabling technologies for such biofoundries as well as their early successes and remaining challenges.

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