Engineering and evolution of saccharomyces cerevisiae to produce biofuels and chemicals

Timothy L. Turner, Heejin Kim, In Iok Kong, Jing Jing Liu, Guo Chang Zhang, Yong-Su Jin

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

To mitigate global climate change caused partly by the use of fossil fuels, the production of fuels and chemicals from renewable biomass has been attempted. The conversion of various sugars from renewable biomass into biofuels by engineered baker’s yeast (Saccharomyces cerevisiae) is one major direction which has grown dramatically in recent years. As well as shifting away from fossil fuels, the production of commodity chemicals by engineered S. cerevisiae has also increased significantly. The traditional approaches of biochemical and metabolic engineering to develop economic bioconversion processes in laboratory and industrial settings have been accelerated by rapid advancements in the areas of yeast genomics, synthetic biology, and systems biology. Together, these innovations have resulted in rapid and efficient manipulation of S. cerevisiae to expand fermentable substrates and diversify value-added products. Here, we discuss recent and major advances in rational (relying on prior experimentally-derived knowledge) and combinatorial (relying on high-throughput screening and genomics) approaches to engineer S. cerevisiae for producing ethanol, butanol, 2,3-butanediol, fatty acid ethyl esters, isoprenoids, organic acids, rare sugars, antioxidants, and sugar alcohols from glucose, xylose, cellobiose, galactose, acetate, alginate, mannitol, arabinose, and lactose.

Original languageEnglish (US)
Title of host publicationAdvances in Biochemical Engineering/Biotechnology
PublisherSpringer Science and Business Media Deutschland GmbH
Pages175-215
Number of pages41
DOIs
StatePublished - Jan 1 2018

Publication series

NameAdvances in Biochemical Engineering/Biotechnology
Volume162
ISSN (Print)0724-6145

Fingerprint

Biofuels
Yeast
Saccharomyces cerevisiae
Fossil Fuels
Bioconversion
Genomics
Biomass
Fossil fuels
Sugars
Synthetic Biology
Sugar Alcohols
Metabolic Engineering
Biochemical engineering
Cellobiose
Sugar Acids
Butanols
Arabinose
Systems Biology
Climate Change
Metabolic engineering

Keywords

  • Biofuels
  • Metabolic engineering
  • Renewable chemicals
  • Saccharomyces cerevisiae
  • Yeast

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

Cite this

Turner, T. L., Kim, H., Kong, I. I., Liu, J. J., Zhang, G. C., & Jin, Y-S. (2018). Engineering and evolution of saccharomyces cerevisiae to produce biofuels and chemicals. In Advances in Biochemical Engineering/Biotechnology (pp. 175-215). (Advances in Biochemical Engineering/Biotechnology; Vol. 162). Springer Science and Business Media Deutschland GmbH. https://doi.org/10.1007/10_2016_22

Engineering and evolution of saccharomyces cerevisiae to produce biofuels and chemicals. / Turner, Timothy L.; Kim, Heejin; Kong, In Iok; Liu, Jing Jing; Zhang, Guo Chang; Jin, Yong-Su.

Advances in Biochemical Engineering/Biotechnology. Springer Science and Business Media Deutschland GmbH, 2018. p. 175-215 (Advances in Biochemical Engineering/Biotechnology; Vol. 162).

Research output: Chapter in Book/Report/Conference proceedingChapter

Turner, TL, Kim, H, Kong, II, Liu, JJ, Zhang, GC & Jin, Y-S 2018, Engineering and evolution of saccharomyces cerevisiae to produce biofuels and chemicals. in Advances in Biochemical Engineering/Biotechnology. Advances in Biochemical Engineering/Biotechnology, vol. 162, Springer Science and Business Media Deutschland GmbH, pp. 175-215. https://doi.org/10.1007/10_2016_22
Turner TL, Kim H, Kong II, Liu JJ, Zhang GC, Jin Y-S. Engineering and evolution of saccharomyces cerevisiae to produce biofuels and chemicals. In Advances in Biochemical Engineering/Biotechnology. Springer Science and Business Media Deutschland GmbH. 2018. p. 175-215. (Advances in Biochemical Engineering/Biotechnology). https://doi.org/10.1007/10_2016_22
Turner, Timothy L. ; Kim, Heejin ; Kong, In Iok ; Liu, Jing Jing ; Zhang, Guo Chang ; Jin, Yong-Su. / Engineering and evolution of saccharomyces cerevisiae to produce biofuels and chemicals. Advances in Biochemical Engineering/Biotechnology. Springer Science and Business Media Deutschland GmbH, 2018. pp. 175-215 (Advances in Biochemical Engineering/Biotechnology).
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