Abstract
Clinical experiences with chemically modified and genetically engineered hemoglobin blood substitutes have uncovered new side-effects that must be addressed before a viable oxygen-carrying alternative to blood can be developed. These include, among others, vasoactivity and rapid autoxidation resulting in free-radical-mediated toxicity. Research is now being directed towards understanding the mechanisms of these toxic side-effects and developing methods of overcoming them.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 534-540 |
| Number of pages | 7 |
| Journal | Current Opinion in Structural Biology |
| Volume | 6 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 1996 |
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology