Engineering and design of blood substitutes

Kevin E. Sanders, Gary Ackers, Stephen Sligar

Research output: Contribution to journalArticlepeer-review


Clinical experiences with chemically modified and genetically engineered hemoglobin blood substitutes have uncovered new side-effects that must be addressed before a viable oxygen-carrying alternative to blood can be developed. These include, among others, vasoactivity and rapid autoxidation resulting in free-radical-mediated toxicity. Research is now being directed towards understanding the mechanisms of these toxic side-effects and developing methods of overcoming them.

Original languageEnglish (US)
Pages (from-to)534-540
Number of pages7
JournalCurrent Opinion in Structural Biology
Issue number4
StatePublished - Aug 1996

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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