Abstract
Clinical experiences with chemically modified and genetically engineered hemoglobin blood substitutes have uncovered new side-effects that must be addressed before a viable oxygen-carrying alternative to blood can be developed. These include, among others, vasoactivity and rapid autoxidation resulting in free-radical-mediated toxicity. Research is now being directed towards understanding the mechanisms of these toxic side-effects and developing methods of overcoming them.
Original language | English (US) |
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Pages (from-to) | 534-540 |
Number of pages | 7 |
Journal | Current Opinion in Structural Biology |
Volume | 6 |
Issue number | 4 |
DOIs | |
State | Published - Aug 1996 |
ASJC Scopus subject areas
- Structural Biology
- Molecular Biology