Contrast agents are utilized in virtually every imaging modality to enhance diagnostic capabilities. We introduce a novel class of optical contrast agent, namely, encapsulating microspheres, that are based not on fluorescence but on scattering nanoparticles within the shell or core. The agents are suitable for reflectionor scattering-based techniques such as optical coherence tomography, light microscopy, and reflectance confocal microscopy. We characterize the optical properties of gold-, melanin-, and carbon-shelled contrast agents and demonstrate enhancement of optical coherence tomography imaging after intravenous injection of such an agent into a mouse.

Original languageEnglish (US)
Pages (from-to)1546-1548
Number of pages3
JournalOptics Letters
Issue number17
StatePublished - Sep 1 2003

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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