Engineered high-affinity human T cell receptors

Sheena N Smith (Inventor), Daniel Thomas Harris (Inventor), David M Kranz (Inventor)

Research output: Patent

Abstract

T cell receptors (TCRs) that have higher affinity for the Survivin antigen are provided. The high affinity TCRs were engineered through the generation of mutational libraries of TCRs in a single-chain format, followed by selection for improved stability and affinity on the surface of yeast (i.e. directed evolution). In embodiments, the engineered TCRs can be used in soluble form for targeted delivery in vivo, or as genes introduced into T cells in an adoptive T cell setting.
Original languageEnglish (US)
U.S. patent number10023625
StatePublished - Jul 17 2018

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