Engineered genetic information processing circuits

Hao Qi, Andrew Blanchard, Ting Lu

Research output: Contribution to journalReview article

Abstract

Cells implement functions through the computation of biological information that is often mediated by genetic regulatory networks. To reprogram cells with novel capabilities, a vast set of synthetic gene circuits has recently been created. These include simple modules, such as feedback circuits, feed-forward loops, ultrasensitive networks, band-pass filters, logic gate operators and others, with each carrying a specific information processing functionality. More advanced cellular computation can also be achieved by assembling multiple simple processing modules into integrated computational cores. Further, when coupled with other modules such as sensors and actuators, integrated processing circuits enable sophisticated biological functionalities at both intra- and intercellular levels. Engineered genetic information processing circuits are transforming our ability to program cells, offering us extraordinary opportunities to explore biological mechanisms and to address real-world challenges.

Original languageEnglish (US)
Pages (from-to)273-287
Number of pages15
JournalWiley Interdisciplinary Reviews: Systems Biology and Medicine
Volume5
Issue number3
DOIs
StatePublished - May 1 2013

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

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