Engineered biosynthesis of natural products in heterologous hosts

Yunzi Luo, Bing Zhi Li, Duo Liu, Lu Zhang, Yan Chen, Bin Jia, Bo Xuan Zeng, Huimin Zhao, Ying Jin Yuan

Research output: Contribution to journalArticlepeer-review


Natural products produced by microorganisms and plants are a major resource of antibacterial and anticancer drugs as well as industrially useful compounds. However, the native producers often suffer from low productivity and titers. Here we summarize the recent applications of heterologous biosynthesis for the production of several important classes of natural products such as terpenoids, flavonoids, alkaloids, and polyketides. In addition, we will discuss the new tools and strategies at multi-scale levels including gene, pathway, genome and community levels for highly efficient heterologous biosynthesis of natural products.

Original languageEnglish (US)
Pages (from-to)5265-5290
Number of pages26
JournalChemical Society Reviews
Issue number15
StatePublished - Aug 7 2015

ASJC Scopus subject areas

  • Chemistry(all)


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