Endotoxin interactions with lipopolysaccharide-responsive cells

Peter S. Tobias, Richard I. Tapping, Julie A. Gegner

Research output: Contribution to journalArticlepeer-review

Abstract

Recent work has identified two proteins that work together to enable many cell types to respond to endotoxin. These two proteins, lipopolysaccharide (LPS) binding protein (LBP) and CD14, also participate in cellular internalization of endotoxin, which may occur independently of cellular activation. Current work with antibodies to LBP and CD14 as well as 'knockout' mice in the context of LPS-initiated endotoxic shock suggests that inhibition of this pathway could be therapeutically useful. These observations point to the need to identify new molecules that mediate LPS- initiated transmembrane signaling and internalization of LPS-protein complexes.

Original languageEnglish (US)
Pages (from-to)476-481
Number of pages6
JournalClinical Infectious Diseases
Volume28
Issue number3
DOIs
StatePublished - 1999

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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