Endothelins in regulating ovarian and oviductal function

Phillip J. Bridges, Jongki Cho, Chemyong Ko

Research output: Contribution to journalArticlepeer-review


In the last 30 years, remarkable progress has been made in our understanding of the biological role of endothelins in the regulation of reproductive function and fertility. A peptide hormone identified for its ability to regulate blood pressure has now been shown as a potent mediator of several reproductive pathways. Ligand- and receptor-specific roles have been identified and/or postulated during follicular development and ovulation as well as in the function and regression of the corpus luteum. In this review we have attempted to organize endothelinmediated ovarian processes in a process-specific manner, rather than compile a review of ligand- or isoform-specific actions. Further, we have included a discussion on "postovarian" or oviductal function, as well as the future directions that we believe will increase our understanding of endothelin biology as a whole.

Original languageEnglish (US)
Pages (from-to)145-155
Number of pages11
JournalFrontiers in Bioscience - Scholar
Volume3 S
Issue number1
StatePublished - Jan 1 2011
Externally publishedYes


  • Corpus Luteum
  • Endothelin
  • Follicle
  • Ovary
  • Oviduct
  • Ovulation
  • Review

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology


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