Endothelin-1 concentrations in clone calves, their surrogate dams, and fetal fluids at birth: Association with oxygen treatment

Pamela A. Wilkins, Raymond Boston, Jonathan E. Palmer, William M. Armstead

Research output: Contribution to journalArticlepeer-review

Abstract

Increased endothelin-1 (ET-1) plasma concentration in human infants is associated with persistent pulmonary hypertension of the newborn, a problem also identified in calves derived from somatic cell clone technology. Increased ET-1 also is present in the amnionic fluid and plasma of the infant and mother in preeclampsia, a condition associated with abnormal placentation. Abnormalities in placentation are identified in clone calves. We measured ET-1 in fetal fluid, calf plasma, and surrogate dam plasma in 40 clone calves at the time of term delivery. Calves were subsequently identified as being either oxygen treated (O2) or non-oxygen treated based on their postpartum clinical course. Fetal fluid ET-1 concentration greater than 1.4 ng/mL carried a 3-fold increase in odds of the calf being treated with oxygen. Maternal plasma ET-1 concentration was greater in the O2 group (13 pg/ mL: [8-23 pg/mL] versus 25 pg/mL [12-40 pg/mL]; median, 25-75 percentile). Plasma ET-1 concentration in calves was not significantly different between groups. Fetal fluid ET-1 may serve as a marker for neonatal disorders of oxygenation in clone calves and the source of ET-1 may be the placenta.

Original languageEnglish (US)
Pages (from-to)594-598
Number of pages5
JournalJournal of veterinary internal medicine
Volume19
Issue number4
DOIs
StatePublished - Jul 2005
Externally publishedYes

Keywords

  • Bovine
  • Nitric oxide
  • Persistent pulmonary hypertension of the neonate
  • Placenta
  • Somatic cell clone

ASJC Scopus subject areas

  • veterinary(all)

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