Endoscopic optical coherence tomography

G. J. Tearney, B. E. Bouma, M. E. Brezinski, S. A. Boppart, C. Pitris, J. F. Southern, E. A. Swanson, J. G. Fujimoto

Research output: Contribution to journalConference articlepeer-review


Optical coherence tomography (OCT) is a recently developed optical imaging technique that uses low coherence interferometry to perform high resolution, cross-sectional imaging in biological systems. While in vitro studies have been performed to demonstrate the feasibility of performing optical biopsy in human tissues, key technologies must be developed to extend this technique to in vivo internal organ systems. These advances include improvements in image acquisition speed, and the development of an OCT compatible catheter-endoscope. A fast scanning OCT system has recently been constructed. This system employs a high power (200 mW) chromium doped forsterite laser as the low coherence source and a piezoelectric fiber stretcher to induce reference arm optical path length delay. The fast scanning system acquires OCT images with an acquisition rate of four images per second, an axial resolution of 15 μm, and a signal to noise ratio of 112 dB. When incorporated with the recently constructed OCT compatible catheter-endoscope, this system is capable of obtaining high resolution endoscopic diagnostic images of tissue microstructure in vivo.

Original languageEnglish (US)
Pages (from-to)2-5
Number of pages4
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - Dec 1 1997
Externally publishedYes
EventProceedings of Optical Tomography and Spectroscopy of Tissue: Theory, Instrumentation, Model and Human Studies II - San Jose, CA, United States
Duration: Feb 9 1997Feb 12 1997


  • Confocal microscopy
  • Endoscopy
  • Medical imaging
  • Multiple scattering
  • Optical coherence tomography
  • Tissue optics

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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