Endocrine-disrupting chemicals in ovarian function: Effects on steroidogenesis, metabolism and nuclear receptor signaling

Zelieann R. Craig, Wei Wang, Jodi A. Flaws

Research output: Contribution to journalReview article

Abstract

Endocrine-disrupting chemicals (EDCs) are exogenous agents with the ability to interfere with processes regulated by endogenous hormones. One such process is female reproductive function. The major reproductive organ in the female is the ovary. Disruptions in ovarian processes by EDCs can lead to adverse outcomes such as anovulation, infertility, estrogen deficiency, and premature ovarian failure among others. This review summarizes the effects of EDCs on ovarian function by describing how they interfere with hormone signaling via two mechanisms: altering the availability of ovarian hormones, and altering binding and activity of the hormone at the receptor level. Among the chemicals covered are pesticides (e.g. dichlorodiphenyltrichloroethane and methoxychlor), plasticizers (e.g. bisphenol A and phthalates), dioxins, polychlorinated biphenyls, and polycyclic aromatic hydrocarbons (e.g. benzo[a]pyrene).

Original languageEnglish (US)
Pages (from-to)633-646
Number of pages14
JournalReproduction
Volume142
Issue number5
DOIs
StatePublished - Nov 1 2011

Fingerprint

Endocrine Disruptors
Cytoplasmic and Nuclear Receptors
Hormones
Methoxychlor
Primary Ovarian Insufficiency
Anovulation
Plasticizers
Dioxins
Benzo(a)pyrene
Polychlorinated Biphenyls
Polycyclic Aromatic Hydrocarbons
Pesticides
Infertility
Ovary
Estrogens

ASJC Scopus subject areas

  • Reproductive Medicine
  • Embryology
  • Endocrinology
  • Obstetrics and Gynecology
  • Cell Biology

Cite this

Endocrine-disrupting chemicals in ovarian function : Effects on steroidogenesis, metabolism and nuclear receptor signaling. / Craig, Zelieann R.; Wang, Wei; Flaws, Jodi A.

In: Reproduction, Vol. 142, No. 5, 01.11.2011, p. 633-646.

Research output: Contribution to journalReview article

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