Enantioselective polyene cyclizations

Chad N. Ungarean, Emma H. Southgate, David Sarlah

Research output: Contribution to journalReview articlepeer-review


The cyclization of polyolefins represents a powerful tool for the rapid generation of molecular complexity. Within the last decade, significant discoveries have been made in the development of methods for converting prochiral polyene substrates into the corresponding polycyclic products with high levels of enantiocontrol. This review highlights advances in the area of enantioselective polyene cyclizations and their use in the synthesis of complex secondary metabolites.

Original languageEnglish (US)
Pages (from-to)5454-5467
Number of pages14
JournalOrganic and Biomolecular Chemistry
Issue number24
StatePublished - 2016

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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