Abstract
A method for the enantioselective synthesis of carbo- and heterocyclic ring systems enabled through the combination of Lewis acid activation and iridium-catalyzed allylic substitution is described. The reaction proceeds with branched, allylic alcohols and carbon nucleophiles as well as heteronucleophiles to give a diverse set of ring systems in good yields and with high enantioselectivities. The utility of the method is highlighted by the asymmetric syntheses of erythrococcamides A and B.
Original language | English (US) |
---|---|
Pages (from-to) | 3235-3238 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 19 |
Issue number | 12 |
DOIs | |
State | Published - Jun 16 2017 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry