Enantioselective Iridium-Catalyzed Allylic Cyclizations

Michael A. Schafroth, Stephan M. Rummelt, David Sarlah, Erick M. Carreira

Research output: Contribution to journalArticlepeer-review

Abstract

A method for the enantioselective synthesis of carbo- and heterocyclic ring systems enabled through the combination of Lewis acid activation and iridium-catalyzed allylic substitution is described. The reaction proceeds with branched, allylic alcohols and carbon nucleophiles as well as heteronucleophiles to give a diverse set of ring systems in good yields and with high enantioselectivities. The utility of the method is highlighted by the asymmetric syntheses of erythrococcamides A and B.

Original languageEnglish (US)
Pages (from-to)3235-3238
Number of pages4
JournalOrganic Letters
Volume19
Issue number12
DOIs
StatePublished - Jun 16 2017

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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