A method for the enantioselective synthesis of carbo- and heterocyclic ring systems enabled through the combination of Lewis acid activation and iridium-catalyzed allylic substitution is described. The reaction proceeds with branched, allylic alcohols and carbon nucleophiles as well as heteronucleophiles to give a diverse set of ring systems in good yields and with high enantioselectivities. The utility of the method is highlighted by the asymmetric syntheses of erythrococcamides A and B.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Jun 16 2017|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry