Enantioselective intramolecular friedel-crafts-type α-arylation of aldehydes

K. C. Nicolaou, Rüdiger Reingruber, David Sarlah, Stefan Bräse

Research output: Contribution to journalArticlepeer-review

Abstract

Enantioselective organo-SOMO catalysis has, in the last two years, been the subject of considerable development and exploration. A number of new and unique transformations have been reported, such as α-allylation, α-oxyamination, α-enolation, and α-vinylation of aldehydes. Herein, we report a modification of this activation mode that involves the intramolecular Friedel-Crafts-type α-arylation of aldehydes carrying electron-donating groups on their aromatic nucleus and its application to the total synthesis of demethyl calamenene, a potent cytotoxic agent against human adenocarcinoma A 549.

Original languageEnglish (US)
Pages (from-to)2086-2087
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number6
DOIs
StatePublished - Feb 18 2009
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry

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