@article{f33407e104c842ae9265b5e7b08a3321,
title = "Enantioselective Allylic C−H Oxidation of Terminal Olefins to Isochromans by Palladium(II)/Chiral Sulfoxide Catalysis",
abstract = "The enantioselective synthesis of isochroman motifs has been accomplished by palladium(II)-catalyzed allylic C−H oxidation from terminal olefin precursors. Critical to the success of this goal was the development and utilization of a novel chiral aryl sulfoxide-oxazoline (ArSOX) ligand. The allylic C−H oxidation reaction proceeds with the broadest scope and highest levels of asymmetric induction reported to date (avg. 92 % ee, 13 examples with greater than 90 % ee).",
keywords = "C−H activation, S ligands, asymmetric catalysis, oxidation, palladium",
author = "Ammann, {Stephen E.} and Wei Liu and White, {M. Christina}",
note = "Funding Information: Financial support provided by the NIH/NIGMS (2R01 GM 076153B). SEA is a NSF Graduate Research Fellow. We thank Rulin Ma for assistance with preliminary studies in ligand design, Connor Delaney for checking the experimental in Figure for 2 h, and Dr. Lingyang Zhu for helpful discussions related to spectral characterization. We thank Dr. Danielle Gray for X-Ray crystallographic analysis. We thank Johnson Matthey for a generous gift of Pd(OAc) Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2016",
month = aug,
day = "8",
doi = "10.1002/anie.201603576",
language = "English (US)",
volume = "55",
pages = "9571--9575",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley & Sons, Ltd.",
number = "33",
}