Empowering Synthesis of Complex Natural Products

Lucas W. Hernandez, David Sarlah

Research output: Contribution to journalReview articlepeer-review


Synthesis of natural products remains a daring task. Their richly diverse and intricate structures often encompass a large degree of unsaturation, contain fused and/or bridged rings, or possess numerous stereogenic centers. Thus, their preparation requires significant synthetic overhead, detracting from their overall practicality as well as hampering the ability of medicinal chemists to synthesize derivatives for pharmaceutical optimization and structure-activity relationship studies. The purpose of this Minireview is to showcase recent examples of efficient total syntheses. Emphasis was not given to the evaluation of ideality or economies (quality), but rather to the practicality (quality with quantity).

Original languageEnglish (US)
Pages (from-to)13248-13270
Number of pages23
JournalChemistry - A European Journal
Issue number58
StatePublished - Oct 17 2019


  • drug design
  • multigram synthesis
  • natural products
  • scalability
  • total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry


Dive into the research topics of 'Empowering Synthesis of Complex Natural Products'. Together they form a unique fingerprint.

Cite this