Abstract

Bone has the natural ability to remodel and repair. Fractures and small noncritical size bone defects undergo regenerative healing via coordinated concurrent development of skeletal and vascular elements in a soft cartilage callus environment. Within this environment bone regeneration recapitulates many of the same cellular and molecular mechanisms that form embryonic bone. Angiogenesis is intimately involved with embryonic bone formation and with both endochondral and intramembranous bone formation in differentiated bone. During bone regeneration osteogenic cells are first associated with vascular tissue in the adjacent periosteal space or the adjacent injured marrow cavity that houses endosteal blood vessels. Critical size bone defects cannot heal without the assistance of therapeutic aids or materials designed to encourage bone regeneration. We discuss the prospects for using synthetic hydrogels in a bioengineering approach to repair critical size bone defects. Hydrogel scaffolds can be designed and fabricated to potentially trigger the same bone morphogenetic cascade that heals bone fractures and noncritical size defects naturally. Lastly, we introduce adult Xenopus laevis hind limb as a novel small animal model system for bone regeneration research. Xenopus hind limbs have been used successfully to screen promising scaffolds designed to heal critical size bone defects.

Original languageEnglish (US)
Title of host publicationNew Perspectives in Regeneration
Pages113-132
Number of pages20
DOIs
StatePublished - Apr 29 2013

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume367
ISSN (Print)0070-217X

Fingerprint

Bone and Bones
Bone Regeneration
Blood Vessels
Osteogenesis
Extremities
Bioengineering
Hydrogels
Hydrogel
Bone Fractures
Xenopus laevis
Bony Callus
Xenopus
Cartilage
Animal Models
Bone Marrow
Research
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)

Cite this

Cameron, J. A., Milner, D. J., Lee, J. S., Cheng, J., Fang, N. X., & Jasiuk, I. M. (2013). Employing the biology of successful fracture repair to heal critical size bone defects. In New Perspectives in Regeneration (pp. 113-132). (Current Topics in Microbiology and Immunology; Vol. 367). https://doi.org/10.1007/82-2012-291

Employing the biology of successful fracture repair to heal critical size bone defects. / Cameron, Jo Ann; Milner, Derek J.; Lee, Jung Seok; Cheng, Jianjun; Fang, Nicholas X.; Jasiuk, Iwona M.

New Perspectives in Regeneration. 2013. p. 113-132 (Current Topics in Microbiology and Immunology; Vol. 367).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cameron, JA, Milner, DJ, Lee, JS, Cheng, J, Fang, NX & Jasiuk, IM 2013, Employing the biology of successful fracture repair to heal critical size bone defects. in New Perspectives in Regeneration. Current Topics in Microbiology and Immunology, vol. 367, pp. 113-132. https://doi.org/10.1007/82-2012-291
Cameron JA, Milner DJ, Lee JS, Cheng J, Fang NX, Jasiuk IM. Employing the biology of successful fracture repair to heal critical size bone defects. In New Perspectives in Regeneration. 2013. p. 113-132. (Current Topics in Microbiology and Immunology). https://doi.org/10.1007/82-2012-291
Cameron, Jo Ann ; Milner, Derek J. ; Lee, Jung Seok ; Cheng, Jianjun ; Fang, Nicholas X. ; Jasiuk, Iwona M. / Employing the biology of successful fracture repair to heal critical size bone defects. New Perspectives in Regeneration. 2013. pp. 113-132 (Current Topics in Microbiology and Immunology).
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