Emerging therapies for intestinal failure

Kelly A. Tappenden

Research output: Contribution to journalArticle

Abstract

Given the immeasurable human distress and health care burden associated with intestinal failure, medical therapies aimed at intestinal rehabilitation are needed. Following massive small-bowel resection, the residual intestine is known to adapt structurally and functionally in an attempt to compensate for the resected portion. However, parenteral nutrition may be associated with many short- and long-term complications, including prevention of intestinal adaptation and promotion of mucosal atrophy due to lack of stimulus provided by oral or enteral nutrition. However, data herein demonstrate that the addition of butyrate, a short-chain fatty acid produced in the colon by dietary fiber fermentation, stimulates intestinal adaptation when added to parenteral nutrition, indicating that current solutions could be formulated to optimize intestinal adaptation and to reduce dependence of individuals with intestinal failure receiving long-term parenteral nutrition regimens.

Original languageEnglish (US)
Pages (from-to)528-532
Number of pages5
JournalArchives of Surgery
Volume145
Issue number6
DOIs
StatePublished - Jun 1 2010

ASJC Scopus subject areas

  • Surgery

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