Emergent properties from dynamicity in biomimetic coordination complexes

Paul J. Griffin, Lisa Olshansky

Research output: Contribution to journalShort surveypeer-review


Many biological metallocofactors exist in dynamic equilibria of electronic and/or structural isomeric forms. Developing metal complexes that mimic this type of dynamicity, we repeatedly observe the emergence of new properties beyond an average of those of the two isomeric forms. These findings suggest that intrinsic conformational dynamicity within metalloprotein active sites may play functional roles in mediating catalysis.

Original languageEnglish (US)
JournalTrends in Chemistry
StateAccepted/In press - 2024


  • bioinorganic
  • conformational fluxionality
  • metallocofactor
  • metalloenzyme

ASJC Scopus subject areas

  • General Chemistry


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