Abstract
Many biological metallocofactors exist in dynamic equilibria of electronic and/or structural isomeric forms. Developing metal complexes that mimic this type of dynamicity, we repeatedly observe the emergence of new properties beyond an average of those of the two isomeric forms. These findings suggest that intrinsic conformational dynamicity within metalloprotein active sites may play functional roles in mediating catalysis.
Original language | English (US) |
---|---|
Pages (from-to) | 424-427 |
Number of pages | 4 |
Journal | Trends in Chemistry |
Volume | 6 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2024 |
Keywords
- bioinorganic
- conformational fluxionality
- metallocofactor
- metalloenzyme
ASJC Scopus subject areas
- General Chemistry