Emergent dynamics of cardiomyocyte clusters on deformable polymeric substrates

Sandeep V. Anand, Taher A. Saif

Research output: Contribution to journalArticle

Abstract

Contractile dynamics of primary cardiomyocyte clusters is studied by culturing them on deformable thin polymeric films. The cell clusters beat and generate sufficient forces to deform the substrates out of plane. Over time, the clusters reorient their force dipoles along the direction of maximum compliance. This suggests that the cells are capable of sensing substrate deformations through a mechanosensitive feedback mechanism and dynamically reorganizing themselves.

Original languageEnglish (US)
Pages (from-to)1-5
Number of pages5
JournalExtreme Mechanics Letters
Volume8
DOIs
StatePublished - Sep 1 2016

Keywords

  • Cardiomyocyte
  • Compliance
  • Dynamics
  • Force dipole
  • Mechanosensitive
  • Thin films

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Engineering (miscellaneous)
  • Mechanics of Materials
  • Mechanical Engineering

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