Abstract
Contractile dynamics of primary cardiomyocyte clusters is studied by culturing them on deformable thin polymeric films. The cell clusters beat and generate sufficient forces to deform the substrates out of plane. Over time, the clusters reorient their force dipoles along the direction of maximum compliance. This suggests that the cells are capable of sensing substrate deformations through a mechanosensitive feedback mechanism and dynamically reorganizing themselves.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-5 |
| Number of pages | 5 |
| Journal | Extreme Mechanics Letters |
| Volume | 8 |
| DOIs | |
| State | Published - Sep 1 2016 |
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Keywords
- Cardiomyocyte
- Compliance
- Dynamics
- Force dipole
- Mechanosensitive
- Thin films
ASJC Scopus subject areas
- Bioengineering
- Chemical Engineering (miscellaneous)
- Engineering (miscellaneous)
- Mechanics of Materials
- Mechanical Engineering
Cite this
Emergent dynamics of cardiomyocyte clusters on deformable polymeric substrates. / Anand, Sandeep V.; Saif, M Taher A.
In: Extreme Mechanics Letters, Vol. 8, 01.09.2016, p. 1-5.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Emergent dynamics of cardiomyocyte clusters on deformable polymeric substrates
AU - Anand, Sandeep V.
AU - Saif, M Taher A
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Contractile dynamics of primary cardiomyocyte clusters is studied by culturing them on deformable thin polymeric films. The cell clusters beat and generate sufficient forces to deform the substrates out of plane. Over time, the clusters reorient their force dipoles along the direction of maximum compliance. This suggests that the cells are capable of sensing substrate deformations through a mechanosensitive feedback mechanism and dynamically reorganizing themselves.
AB - Contractile dynamics of primary cardiomyocyte clusters is studied by culturing them on deformable thin polymeric films. The cell clusters beat and generate sufficient forces to deform the substrates out of plane. Over time, the clusters reorient their force dipoles along the direction of maximum compliance. This suggests that the cells are capable of sensing substrate deformations through a mechanosensitive feedback mechanism and dynamically reorganizing themselves.
KW - Cardiomyocyte
KW - Compliance
KW - Dynamics
KW - Force dipole
KW - Mechanosensitive
KW - Thin films
UR - http://www.scopus.com/inward/record.url?scp=84947757208&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84947757208&partnerID=8YFLogxK
U2 - 10.1016/j.eml.2015.09.008
DO - 10.1016/j.eml.2015.09.008
M3 - Article
AN - SCOPUS:84947757208
VL - 8
SP - 1
EP - 5
JO - Extreme Mechanics Letters
JF - Extreme Mechanics Letters
SN - 2352-4316
ER -