Emergent dynamics of cardiomyocyte clusters on deformable polymeric substrates

Sandeep V. Anand; Taher A. Saif

doi:10.1016/j.eml.2015.09.008

Emergent dynamics of cardiomyocyte clusters on deformable polymeric substrates

Research output: Contribution to journal › Article

Abstract

Contractile dynamics of primary cardiomyocyte clusters is studied by culturing them on deformable thin polymeric films. The cell clusters beat and generate sufficient forces to deform the substrates out of plane. Over time, the clusters reorient their force dipoles along the direction of maximum compliance. This suggests that the cells are capable of sensing substrate deformations through a mechanosensitive feedback mechanism and dynamically reorganizing themselves.

Original language	English (US)
Pages (from-to)	1-5
Number of pages	5
Journal	Extreme Mechanics Letters
Volume	8
DOIs	https://doi.org/10.1016/j.eml.2015.09.008
State	Published - Sep 1 2016

Keywords

Cardiomyocyte
Compliance
Dynamics
Force dipole
Mechanosensitive
Thin films

ASJC Scopus subject areas

Bioengineering
Chemical Engineering (miscellaneous)
Engineering (miscellaneous)
Mechanics of Materials
Mechanical Engineering

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10.1016/j.eml.2015.09.008

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Anand, S. V., & Saif, T. A. (2016). Emergent dynamics of cardiomyocyte clusters on deformable polymeric substrates. Extreme Mechanics Letters, 8, 1-5. https://doi.org/10.1016/j.eml.2015.09.008

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