Abstract
Contractile dynamics of primary cardiomyocyte clusters is studied by culturing them on deformable thin polymeric films. The cell clusters beat and generate sufficient forces to deform the substrates out of plane. Over time, the clusters reorient their force dipoles along the direction of maximum compliance. This suggests that the cells are capable of sensing substrate deformations through a mechanosensitive feedback mechanism and dynamically reorganizing themselves.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-5 |
| Number of pages | 5 |
| Journal | Extreme Mechanics Letters |
| Volume | 8 |
| DOIs | |
| State | Published - Sep 1 2016 |
Keywords
- Cardiomyocyte
- Compliance
- Dynamics
- Force dipole
- Mechanosensitive
- Thin films
ASJC Scopus subject areas
- Bioengineering
- Chemical Engineering (miscellaneous)
- Engineering (miscellaneous)
- Mechanics of Materials
- Mechanical Engineering