Emergence and Characterization of the p23 molecular chaperone

Frank J. Echtenkamp, Brian C. Freeman

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The p23 molecular chaperone is an abundant eukaryotic protein that shares genetic and physical connections to a variety of proteins working in diverse biological processes including protein transport, ribosome biogenesis, transcription activation, and chromatin remodeling. Here, we describe the initial founding of the p23 chaperone along with the early discoveries related to p23's function, its relationship to small heat shock proteins and other CHORD and Sgt1 (CS)-domaincontaining factors, p23's biological relevancies in different cellular pathways, and how this chaperone has been exploited by both parasites and viruses. Finally, we discuss the correlation between p23 levels and cancerous cell growth.

Original languageEnglish (US)
Title of host publicationThe Molecular Chaperones Interaction Networks in Protein Folding and Degradation
PublisherSpringer
Pages207-232
Number of pages26
ISBN (Electronic)9781493911301
ISBN (Print)9781493911295
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • General Agricultural and Biological Sciences
  • General Biochemistry, Genetics and Molecular Biology
  • General Medicine

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