Abstract
The p23 molecular chaperone is an abundant eukaryotic protein that shares genetic and physical connections to a variety of proteins working in diverse biological processes including protein transport, ribosome biogenesis, transcription activation, and chromatin remodeling. Here, we describe the initial founding of the p23 chaperone along with the early discoveries related to p23's function, its relationship to small heat shock proteins and other CHORD and Sgt1 (CS)-domaincontaining factors, p23's biological relevancies in different cellular pathways, and how this chaperone has been exploited by both parasites and viruses. Finally, we discuss the correlation between p23 levels and cancerous cell growth.
Original language | English (US) |
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Title of host publication | The Molecular Chaperones Interaction Networks in Protein Folding and Degradation |
Publisher | Springer |
Pages | 207-232 |
Number of pages | 26 |
ISBN (Electronic) | 9781493911301 |
ISBN (Print) | 9781493911295 |
DOIs | |
State | Published - Jan 1 2014 |
ASJC Scopus subject areas
- General Agricultural and Biological Sciences
- General Biochemistry, Genetics and Molecular Biology
- General Medicine