Abstract
A wealth of information from diverse disciplines has yielded exquisite insight into the aaRSs' interactions with substrates and catalytic mechanisms. The discovery of fascinating new roles also reflects a vast network of functional activities that extends far beyond the aminoacylation reaction. Full realization of the aaRSs' diverse and essential functional roles will not only present evolutionary models for the development of the cell, but also provide enormous opportunities for pharmaceutical advances.
Original language | English (US) |
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Pages (from-to) | 4591-4596 |
Number of pages | 6 |
Journal | EMBO Journal |
Volume | 18 |
Issue number | 17 |
DOIs | |
State | Published - Sep 1 1999 |
Externally published | Yes |
Keywords
- Aminoacyl-tRNA synthetases
- Aminoacylation
- Antibiotic
- Protein synthesis
- tRNA
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- General Biochemistry, Genetics and Molecular Biology
- General Immunology and Microbiology