A wealth of information from diverse disciplines has yielded exquisite insight into the aaRSs' interactions with substrates and catalytic mechanisms. The discovery of fascinating new roles also reflects a vast network of functional activities that extends far beyond the aminoacylation reaction. Full realization of the aaRSs' diverse and essential functional roles will not only present evolutionary models for the development of the cell, but also provide enormous opportunities for pharmaceutical advances.
- Aminoacyl-tRNA synthetases
- Protein synthesis
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)