Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin

Julian D. Hegemann, Christopher J. Schwalen, Douglas A. Mitchell, Wilfred A. Van der Donk

Research output: Contribution to journalArticlepeer-review

Abstract

Substrate binding assays, in vitro proteolytic processing assays, and heterologous lasso peptide production were used to investigate the roles of conserved precursor peptide residues during paeninodin maturation. Specifically, we delineate which residues are important for substrate recognition, proteolysis, and lasso peptide macrocyclization.

Original languageEnglish (US)
Pages (from-to)9007-9010
Number of pages4
JournalChemical Communications
Volume54
Issue number65
DOIs
StatePublished - 2018

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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