Element mapping in organic samples utilizing a benchtop X-Ray Fluorescence Emission Tomography (XFET) system

A. Groll, J. George, P. Vargas, P. J. La Riviere, Ling Jian Meng

Research output: Contribution to journalArticle

Abstract

X-ray fluorescence computed tomography (XFCT) is an emerging imaging modality that maps the three-dimensional distribution of elements, generally metals, in ex vivo specimens and potentially in living animals and humans. Building on our previous synchrotron-based work, we experimentally explored the use of a benchtop X-ray fluorescence computed tomography system for mapping trace-metal ions in biological samples. This system utilizes a scanning pencil beam to stimulate the object and then relies on a detection system, with single or multiple slit apertures placed in front of position-sensitive X-ray detectors, to collect the fluorescence X-rays and to form 3-D elemental map without the need for tomographic imaging reconstruction. The technique was used to generate images of the elemental distributions of a triple-tube phantom and an osmium-stained zebrafish.

Original languageEnglish (US)
Article number7275067
Pages (from-to)2310-2317
Number of pages8
JournalIEEE Transactions on Nuclear Science
Volume62
Issue number5
DOIs
StatePublished - Oct 1 2015

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Keywords

  • Apertures
  • CCD image sensors
  • X-ray applications
  • X-ray detection
  • biomedical imaging
  • flourescence

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Nuclear Energy and Engineering
  • Electrical and Electronic Engineering

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