Electrothermal soft manipulator enabling safe transport and handling of thin cell/tissue sheets and bioelectronic devices

Byoung Soo Kim; Min Ku Kim; Younghak Cho; Eman E. Hamed; Martha U. Gillette; Hyeongyun Cha; Nenad Miljkovic; Vinay K. Aakalu; Kai Kang; Kyung No Son; Kyle M. Schachtschneider; Lawrence B. Schook; Chenfei Hu; Gabriel Popescu; Yeonsoo Park; William C. Ballance; Seunggun Yu; Sung Gap Im; Jonghwi Lee; Chi Hwan Lee; Hyunjoon Kong

doi:10.1126/sciadv.abc5630

Electrothermal soft manipulator enabling safe transport and handling of thin cell/tissue sheets and bioelectronic devices

Byoung Soo Kim, Min Ku Kim, Younghak Cho, Eman E. Hamed, Martha U. Gillette, Hyeongyun Cha, Nenad Miljkovic, Vinay K. Aakalu, Kai Kang, Kyung No Son, Kyle M. Schachtschneider, Lawrence B. Schook, Chenfei Hu, Gabriel Popescu, Yeonsoo Park, William C. Ballance, Seunggun Yu, Sung Gap Im, Jonghwi Lee, Chi Hwan LeeHyunjoon Kong

Research output: Contribution to journal › Article › peer-review

Abstract

“Living” cell sheets or bioelectronic chips have great potentials to improve the quality of diagnostics and therapies. However, handling these thin and delicate materials remains a grand challenge because the external force applied for gripping and releasing can easily deform or damage the materials. This study presents a soft manipulator that can manipulate and transport cell/tissue sheets and ultrathin wearable biosensing devices seamlessly by recapitulating how a cephalopod’s suction cup works. The soft manipulator consists of an ultrafast thermo-responsive, microchanneled hydrogel layer with tissue-like softness and an electric heater layer. The electric current to the manipulator drives microchannels of the gel to shrink/expand and results in a pressure change through the microchannels. The manipulator can lift/detach an object within 10 s and can be used repeatedly over 50 times. This soft manipulator would be highly useful for safe and reliable assembly and implantation of therapeutic cell/tissue sheets and biosensing devices.

Original language	English (US)
Article number	eabc5630
Journal	Science Advances
Volume	6
Issue number	42
DOIs	https://doi.org/10.1126/sciadv.abc5630
State	Published - Oct 16 2020

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Kim, B. S., Kim, M. K., Cho, Y., Hamed, E. E., Gillette, M. U., Cha, H., Miljkovic, N., Aakalu, V. K., Kang, K., Son, K. N., Schachtschneider, K. M., Schook, L. B., Hu, C., Popescu, G., Park, Y., Ballance, W. C., Yu, S., Im, S. G., Lee, J., ... Kong, H. (2020). Electrothermal soft manipulator enabling safe transport and handling of thin cell/tissue sheets and bioelectronic devices. Science Advances, 6(42), Article eabc5630. https://doi.org/10.1126/sciadv.abc5630

Kim, BS, Kim, MK, Cho, Y, Hamed, EE, Gillette, MU, Cha, H, Miljkovic, N, Aakalu, VK, Kang, K, Son, KN, Schachtschneider, KM, Schook, LB, Hu, C, Popescu, G, Park, Y, Ballance, WC, Yu, S, Im, SG, Lee, J, Lee, CH & Kong, H 2020, 'Electrothermal soft manipulator enabling safe transport and handling of thin cell/tissue sheets and bioelectronic devices', Science Advances, vol. 6, no. 42, eabc5630. https://doi.org/10.1126/sciadv.abc5630

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abstract = "“Living” cell sheets or bioelectronic chips have great potentials to improve the quality of diagnostics and therapies. However, handling these thin and delicate materials remains a grand challenge because the external force applied for gripping and releasing can easily deform or damage the materials. This study presents a soft manipulator that can manipulate and transport cell/tissue sheets and ultrathin wearable biosensing devices seamlessly by recapitulating how a cephalopod{\textquoteright}s suction cup works. The soft manipulator consists of an ultrafast thermo-responsive, microchanneled hydrogel layer with tissue-like softness and an electric heater layer. The electric current to the manipulator drives microchannels of the gel to shrink/expand and results in a pressure change through the microchannels. The manipulator can lift/detach an object within 10 s and can be used repeatedly over 50 times. This soft manipulator would be highly useful for safe and reliable assembly and implantation of therapeutic cell/tissue sheets and biosensing devices.",

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AU - Miljkovic, Nenad

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AU - Schachtschneider, Kyle M.

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AU - Hu, Chenfei

AU - Popescu, Gabriel

AU - Park, Yeonsoo

AU - Ballance, William C.

AU - Yu, Seunggun

AU - Im, Sung Gap

AU - Lee, Jonghwi

AU - Lee, Chi Hwan

AU - Kong, Hyunjoon

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Electrothermal soft manipulator enabling safe transport and handling of thin cell/tissue sheets and bioelectronic devices

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