TY - JOUR
T1 - Electronic sensor and actuator webs for large-area complex geometry cardiac mapping and therapy
AU - Kim, Dae Hyeong
AU - Ghaffari, Roozbeh
AU - Lu, Nanshu
AU - Wang, Shuodao
AU - Lee, Stephen P.
AU - Keum, Hohyun
AU - D'Angelo, Robert
AU - Klinker, Lauren
AU - Su, Yewang
AU - Lu, Chaofeng
AU - Kim, Yun Soung
AU - Ameen, Abid
AU - Li, Yuhang
AU - Zhang, Yihui
AU - De Graff, Bassel
AU - Hsu, Yung Yu
AU - Liu, Zhuang Jian
AU - Ruskin, Jeremy
AU - Xu, Lizhi
AU - Lu, Chi
AU - Omenetto, Fiorenzo G.
AU - Huang, Yonggang
AU - Mansour, Moussa
AU - Slepian, Marvin J.
AU - Rogers, John A.
PY - 2012/12/4
Y1 - 2012/12/4
N2 - Curved surfaces, complex geometries, and time-dynamic deformations of the heart create challenges in establishing intimate, non-constraining interfaces between cardiac structures and medical devices or surgical tools, particularly over large areas. We constructed large area designs for diagnostic and therapeutic stretchable sensor and actuator webs that conformally wrap the epicardium, establishing robust contact without sutures, mechanical fixtures, tapes, or surgical adhesives. These multifunctional web devices exploit open, mesh layouts and mount on thin, bio-resorbable sheets of silk to facilitate handling in a way that yields, after dissolution, exceptionally low mechanical moduli and thicknesses. In vivo studies in rabbit and pig animal models demonstrate the effectiveness of these device webs for measuring and spatially mapping temperature, electrophysiological signals, strain, and physical contact in sheet and balloon-based systems that also have the potential to deliver energy to perform localized tissue ablation.
AB - Curved surfaces, complex geometries, and time-dynamic deformations of the heart create challenges in establishing intimate, non-constraining interfaces between cardiac structures and medical devices or surgical tools, particularly over large areas. We constructed large area designs for diagnostic and therapeutic stretchable sensor and actuator webs that conformally wrap the epicardium, establishing robust contact without sutures, mechanical fixtures, tapes, or surgical adhesives. These multifunctional web devices exploit open, mesh layouts and mount on thin, bio-resorbable sheets of silk to facilitate handling in a way that yields, after dissolution, exceptionally low mechanical moduli and thicknesses. In vivo studies in rabbit and pig animal models demonstrate the effectiveness of these device webs for measuring and spatially mapping temperature, electrophysiological signals, strain, and physical contact in sheet and balloon-based systems that also have the potential to deliver energy to perform localized tissue ablation.
KW - Cardiac electrophysiology
KW - Flexible electronics
KW - Implantable biomedical devices
KW - Semiconductor nanomaterials
KW - Stretchable electronics
UR - http://www.scopus.com/inward/record.url?scp=84870606745&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84870606745&partnerID=8YFLogxK
U2 - 10.1073/pnas.1205923109
DO - 10.1073/pnas.1205923109
M3 - Article
C2 - 23150574
AN - SCOPUS:84870606745
SN - 0027-8424
VL - 109
SP - 19910
EP - 19915
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 49
ER -