Electron transfer from cytochrome b5 to cytochrome c

Bill Durham, Jill L. Fairris, Mark McLean, Frank Millett, Jill R. Scott, Stephen G. Sligar, Anne Willie

Research output: Contribution to journalArticlepeer-review


The reaction of cytochrome b5 with cytochrome c has become a very prominent system for investigating fundamental questions regarding interprotein electron transfer. One of the first computer modeling studies of electron transfer and protein/protein interaction was reported using this system. Subsequently, numerous studies focused on the experimental determination of the features which control protein/protein interactions. Kinetic measurements of the intracomplex electron transfer reaction have only appeared in the last 10 years. The current review will provide a summary of the kinetic measurements and a critical assessment of the interpretation of these experiments.

Original languageEnglish (US)
Pages (from-to)331-340
Number of pages10
JournalJournal of Bioenergetics and Biomembranes
Issue number3
StatePublished - Jun 1995


  • Cytochrome b
  • cytochrome c
  • electron transfer
  • kinetics
  • ruthenium

ASJC Scopus subject areas

  • Physiology
  • Cell Biology


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