Electrocardiographic findings in 130 hospitalized neonatal calves with diarrhea and associated potassium balance disorders

Florian M. Trefz, Ingrid Lorenz, Peter D. Constable

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Hyperkalemia in neonatal diarrheic calves can potentially result in serious cardiac conduction abnormalities and arrhythmias. Objectives: To document electrocardiographic (ECG) findings and the sequence of ECG changes that are associated with increasing plasma potassium concentrations (cK+) in a large population of neonatal diarrheic calves. Animals: One hundred and thirty neonatal diarrheic calves (age ≤21 days). Methods: Prospective observational study involving calves admitted to a veterinary teaching hospital. Results: Hyperkalemic calves (cK+: 5.8-10.2, blood pH: 6.55-7.47) had significantly (P <.05) longer QRS durations as well as deeper S wave, higher T wave, and higher ST segment amplitudes in lead II than calves, which had both venous blood pH and cK+ within the reference range. The first ECG changes in response to an increase in cK+ were an increase in voltages of P, Ta, S, and T wave amplitudes. Segmented linear regression indicated that P wave amplitude decreased when cK+ >6.5 mmol/L, S wave amplitude voltage decreased when cK+ >7.4 mmol/L, QRS duration increased when cK+ >7.8 mmol/L, J point amplitude increased when cK+ >7.9 mmol/L, and ST segment angle increased when cK+ >9.1 mmol/L. P wave amplitude was characterized by a second common break point at cK+ = 8.2 mmol/L, above which value the amplitude was 0. Conclusions and Clinical Importance: Hyperkalemia in neonatal diarrheic calves is associated with serious cardiac conduction abnormalities. In addition to increased S and T wave amplitude voltages, alterations of P and Ta wave amplitudes are early signs of hyperkalemia, which is consistent with the known sensitivity of atrial myocytes to increased cK+.

Original languageEnglish (US)
Pages (from-to)1447-1461
Number of pages15
JournalJournal of veterinary internal medicine
Volume32
Issue number4
DOIs
StatePublished - Jul 1 2018

Keywords

  • acidemia
  • calves
  • electrocardiography
  • hyperkalemia
  • hypokalemia

ASJC Scopus subject areas

  • veterinary(all)

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