Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors

Ee Ling Gui, Lain Jong Li, P. S. Lee, Anup Lohani, S. G. Mhaisalkar, Qing Cao, Seong Jun Kang, John A. Rogers, N. C. Tansil, Zhiqiang Gao

Research output: Contribution to journalArticle

Abstract

The authors study deoxyribonucleic acid (DNA) sensing characteristics of carbon nanotube network field-effect transistors (CNNFETs) by monitoring their electrical responses upon immobilization with a DNA probe, hybridization with DNA analytes, and intercalation with a N, N′ -bis(3-propylimidazole)-1,4, 5,8-naphthalene diimide modified with Os (2, 2′ -bipyridine)2 Cl+ pendants. The CNNFETs immobilized by single-stranded DNA molecules demonstrate the selective sensing of its complementary and single-base mismatched DNA (difference of ∼16% in reduction of normalized drain current Id). Subsequent intercalation demonstrates a further sensitivity enhancement (difference of ∼13% in Id reduction) due to specific binding between hybridized DNA and intercalators, corroborated by the x-ray photoelectron spectroscopy study.

Original languageEnglish (US)
Article number232104
JournalApplied Physics Letters
Volume89
Issue number23
DOIs
StatePublished - Dec 18 2006

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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    Gui, E. L., Li, L. J., Lee, P. S., Lohani, A., Mhaisalkar, S. G., Cao, Q., Kang, S. J., Rogers, J. A., Tansil, N. C., & Gao, Z. (2006). Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors. Applied Physics Letters, 89(23), [232104]. https://doi.org/10.1063/1.2399355