Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors

Ee Ling Gui, Lain Jong Li, P. S. Lee, Anup Lohani, S. G. Mhaisalkar, Qing Cao, Seong Jun Kang, John A Rogers, N. C. Tansil, Zhiqiang Gao

Research output: Contribution to journalArticle

Abstract

The authors study deoxyribonucleic acid (DNA) sensing characteristics of carbon nanotube network field-effect transistors (CNNFETs) by monitoring their electrical responses upon immobilization with a DNA probe, hybridization with DNA analytes, and intercalation with a N, N′ -bis(3-propylimidazole)-1,4, 5,8-naphthalene diimide modified with Os (2, 2′ -bipyridine)2 Cl+ pendants. The CNNFETs immobilized by single-stranded DNA molecules demonstrate the selective sensing of its complementary and single-base mismatched DNA (difference of ∼16% in reduction of normalized drain current Id). Subsequent intercalation demonstrates a further sensitivity enhancement (difference of ∼13% in Id reduction) due to specific binding between hybridized DNA and intercalators, corroborated by the x-ray photoelectron spectroscopy study.

Original languageEnglish (US)
Article number232104
JournalApplied Physics Letters
Volume89
Issue number23
DOIs
StatePublished - Dec 18 2006

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intercalation
field effect transistors
deoxyribonucleic acid
carbon nanotubes
immobilization
naphthalene
x ray spectroscopy
photoelectron spectroscopy
augmentation
probes
sensitivity
molecules

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Cite this

Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors. / Gui, Ee Ling; Li, Lain Jong; Lee, P. S.; Lohani, Anup; Mhaisalkar, S. G.; Cao, Qing; Kang, Seong Jun; Rogers, John A; Tansil, N. C.; Gao, Zhiqiang.

In: Applied Physics Letters, Vol. 89, No. 23, 232104, 18.12.2006.

Research output: Contribution to journalArticle

Gui, Ee Ling ; Li, Lain Jong ; Lee, P. S. ; Lohani, Anup ; Mhaisalkar, S. G. ; Cao, Qing ; Kang, Seong Jun ; Rogers, John A ; Tansil, N. C. ; Gao, Zhiqiang. / Electrical detection of hybridization and threading intercalation of deoxyribonucleic acid using carbon nanotube network field-effect transistors. In: Applied Physics Letters. 2006 ; Vol. 89, No. 23.
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AU - Lohani, Anup

AU - Mhaisalkar, S. G.

AU - Cao, Qing

AU - Kang, Seong Jun

AU - Rogers, John A

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AU - Gao, Zhiqiang

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