As the future of health care diagnostics moves toward more portable and personalized techniques, there is immense potential to harness the power of electrical signals for biological sensing and diagnostic applications at the point of care. Electrical biochips can be used to both manipulate and sense biological entities, as they can have several inherent advantages, including on-chip sample preparation, label-free detection, reduced cost and complexity, decreased sample volumes, increased portability, and large-scale multiplexing. The advantages of fully integrated electrical biochip platforms are particularly attractive for point-of-care systems. This review summarizes these electrical lab-on-a-chip technologies and highlights opportunities to accelerate the transition from academic publications to commercial success.

Original languageEnglish (US)
Pages (from-to)329-355
Number of pages27
JournalAnnual Review of Biomedical Engineering
StatePublished - Jul 11 2016


  • Biochip
  • Biosensor
  • Chips
  • Diagnostics
  • Electrical
  • Label-free
  • Microfabrication
  • Point-of-care

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering


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