Elastostatics of a spherical inclusion in homogeneous biological media

Mehmet Bilgen, Michael F. Insana

Research output: Contribution to journalArticle

Abstract

A three dimensional spherical inclusion model that approximates a lesion bonded to a tissue matrix is proposed for biomedical elastography. Analytical formulae describing spatial strain and stress distributions generated in infinite media by uniform loading are given under a linear homogeneous isotropic elasticity assumption. Strain and stress distribution are also calculated using finite-element analysis (FEA) for a variety of cases to determine the effects of shear modulus distribution, external loading conditions (uniform stress versus uniform displacement compressor size and matrix dimensions on the elastostatics of the tissue. Analytical strain and stress predictions are shown to agree with the FEA results to within 10% accuracy provided that the matrix dimensions are at least ten times that of the inclusion. Also for these cases uniform stress boundary conditions can be equivalently represented by uniform displacement of the boundary. Spherical inclusions exhibit a lower efficiency for transferring elastic shear modulus contrast into strain contrast than cylindrical or planar inclusions. Additional compression will increase the strain contrast. However large compressions also lead to increases in ultrasonic signal decorrelation and strain and stress concentrations in the homogeneous matrix around the inclusion. Although strain concentrations may help describe the boundaries of the inclusion more clearly, they also increase the risk of damaging the tissue. Understanding the strains and stress distributions in a biological tissue containing a lesion is necessary for optimizing the experimental configurations and consequently improving the diagnostic values of elasticity imaging.

Original languageEnglish (US)
Pages (from-to)1-20
Number of pages20
JournalPhysics in medicine and biology
Volume43
Issue number1
DOIs
StatePublished - Mar 19 1998
Externally publishedYes

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Elastostatics of a spherical inclusion in homogeneous biological media'. Together they form a unique fingerprint.

  • Cite this