Elastomeric 2D grating and hemispherical optofluidic chamber for multifunctional fluidic sensing

Zhida Xu, Xinhao Wang, Kevin Han, Shuo Li, G. Logan Liu

Research output: Contribution to journalArticlepeer-review


We present an optofluidic sensor based on an elastomeric two-dimensional (2D) grating integrated inside a hemispherical fluid chamber. A laser beam is diffracted before (reflection) and after (transmission) going through the grating and liquid in the dome chamber. The sensing mechanism is investigated and simulated with a finite-difference time-domain-based electromagnetic method. For the experiment, by analyzing the size, power, and shape of the 2D diffraction patterns, we can retrieve multiple parameters of the liquid, including the refractive index, pressure, and opacity with high sensitivity. We demonstrate that the glucose concentration can be monitored when mixed in a different concentrated phosphate-buffered saline solution. The free-solution binding of bovine serum albumin (BSA) and anti-BSA IgG is detected with this optical sensor. This low-cost, multifunctional, and reliable optofluidic sensor has the potential to be used as a monitor of biofluid, such as blood in hemodialysis.

Original languageEnglish (US)
Pages (from-to)2466-2472
Number of pages7
JournalJournal of the Optical Society of America A: Optics and Image Science, and Vision
Issue number12
StatePublished - Dec 1 2013
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Computer Vision and Pattern Recognition


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