Elastic rod model of a DNA loop in the lac operon

Alexander Balaeff, L. Mahadevan, Klaus Schulten

Research output: Contribution to journalArticlepeer-review


We use the theory of elasticity to compute the shape of the DNA loop bridging the gap in the crystal structure of the lac repressor-DNA complex. The Kirchhoff system of equations with boundary conditions derived from the crystal structure is solved using a continuation method. This approach can be applied effectively to find coarse-grained conformational minima of DNA loops.

Original languageEnglish (US)
Pages (from-to)4900-4903
Number of pages4
JournalPhysical review letters
Issue number23
StatePublished - Jan 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • General Physics and Astronomy


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