Efficient synthesis of enantiopure β-amino-γ-keto acids from L-homoserine

Anil K. Sharma, Paul J. Hergenrother

Research output: Contribution to journalArticlepeer-review


(Matrix presented) A variety of β-amino-γ-keto acids were prepared in four steps from commercially available L-homoserine. The reaction sequence is highlighted by a Ni-catalyzed Grignard addition to a N-protected derivative of L-homoserine. One of the β-amino-γ-keto acids was then used to create a β-peptide trimer composed solely of β-amino-γ -keto acids.

Original languageEnglish (US)
Pages (from-to)2107-2109
Number of pages3
JournalOrganic Letters
Issue number12
StatePublished - Jun 12 2003

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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