Abstract
(Matrix presented) A variety of β-amino-γ-keto acids were prepared in four steps from commercially available L-homoserine. The reaction sequence is highlighted by a Ni-catalyzed Grignard addition to a N-protected derivative of L-homoserine. One of the β-amino-γ-keto acids was then used to create a β-peptide trimer composed solely of β-amino-γ -keto acids.
Original language | English (US) |
---|---|
Pages (from-to) | 2107-2109 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 5 |
Issue number | 12 |
DOIs | |
State | Published - Jun 12 2003 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry