Abstract
Closing the loop: The artificial 6BX22 deoxyribozyme (in green) synthesizes naturally occurring lariat RNAs in one step from readily available linear RNA substrates. The exquisite site selectivity of this macrocyclization reaction - which can form a 1597-membered ring in 72% yield with < 0.1 % side products - highlights the utility of catalytic DNA for transformations that are not possible with traditional synthetic methods. (Chemical Equation Presented).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5863-5866 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 44 |
| Issue number | 36 |
| DOIs | |
| State | Published - Sep 4 2005 |
Keywords
- DNA
- Deoxyribozymes
- Enzyme catalysis
- Lariat RNA
- Macrocycles
ASJC Scopus subject areas
- Catalysis
- General Chemistry